Suzuki Lab.

Division of Molecular Oncology
Nagoya University Graduate School of Medicine

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Hiroshi I. Suzuki, MD, PHD

2020 PresentNagoya University Professor
20192020 Massachusetts Institute of Technology Koch Institute for Integrative Cancer Research Research Scientist
20142019 Massachusetts Institute of Technology Koch Institute for Integrative Cancer Research Visiting Scientist
20102014 Graduate School of Medicine, The University of Tokyo Department of Molecular Pathology Project Assistant Professor
20082010 Japan Society for the Promotion of Science Research Fellowship for Young Scientists
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Email: hisuzuki@med.nagoya-u.ac.jp

Sachi Kozawa Technical staff

Shintaro Komatsu, MBBSResearcher

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Koichi Ogami, PhDAssistant professor

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Email: koichi.ogami@med.nagoya-u.ac.jp

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Koh Onimaru, PhDAssistant professor

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Email: koh.onimaru@med.nagoya-u.ac.jp

Seiko Yoshino, PhDDesignated assistant professor

Hitomi Mizuno

About our lab

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The mission of our laboratory is to elucidate the function and mechanism of genome and RNA and to apply them to better understand the molecular mechanisms of cancer and to develop the new approaches to cancer therapy. How do genes work? This fundamental question is crucial to understand the mechanisms of diverse diseases including cancer, which involve the interactions between genetic factors and environmental factors. Through an integrative omics analysis based on next-generation sequencing, bioinformatics, and genome/RNA engineering, we aim to get a deeper understanding of the relationships between genome, epigenome, transcription, and RNA to uncover the operating principles of gene regulation and disease mechanisms. We also aim to facilitate cancer precision medicine based on comprehensive omics analysis and develop new methodologies and technologies to advance this.

Research line 1: MicroRNA and Cancer

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Research line 2: Systems RNA Biology

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Research line 3: Biology of Transcription (1): Super-enhancer and Phase Separation

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Research line 4: Biology of Transcription (2): Transcription Cycle

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Research line 5: Multi-Omics Analysis in Cancer

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Beyond

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Selected publications

  1. Ochi Y, Kon A, ..(31 authors).. Suzuki HI, Ogawa S. Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes. Cancer Discov. 2020 Jun;10(6):836-853.
  2. Grigelioniene G, Suzuki HI, Taylan F, Mirzamohammadi F, Borochowitz ZU, Ayturk UM, Tzur S, Horemuzova E, Lindstrand A, Weis MA, Grigelionis G, Hammarsjö A, Marsk E, Nordgren A, Nordenskjöld M, Eyre DR, Warman ML, Nishimura G, Sharp PA, Kobayashi T. Gain-of-function mutation of microRNA-140 in human skeletal dysplasia. Nat Med. 2019 Apr;25(4):583-590. Epub 2019 Feb 25.
  3. Suzuki HI, Spengler RM, Grigelioniene G, Kobayashi T, Sharp PA. Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics. Nat Genet. 2018; 50(5): 657-661.
  4. Chiu AC, Suzuki HI, Wu X, Mahat DB, Kriz AJ, Sharp PA. Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP. Mol Cell. 2018; 15; 69(4): 648-663.e7.
  5. Suzuki HI, Young RA, Sharp PA. Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis. Cell, 2017; 168(6): 1000-1014.
  6. Suzuki HI, Katsura A, Yasuda T, Ueno T, Mano H, Sugimoto K, Miyazono K. Small-RNA asymmetry is directly driven by mammalian Argonautes. Nat. Struct. Mol. Biol. 2015; 22(7): 512-521.
  7. Suzuki HI, Matsuyama H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K, Miyazono K. Computational dissection of distinct microRNA activity signatures associated with peripheral T cell lymphoma subtypes. Leukemia, 2013; 27(10): 2107-2111.
  8. Suzuki HI, Mihira H, Watabe T, Sugimoto K, Miyazono K. Widespread inference of weighted microRNA-mediated gene regulation in cancer transcriptome analysis. Nucleic Acids Res. 2013; 1; 41(5): e62.
  9. Suzuki HI, Arase M, Matsuyama H, Choi YL, Ueno T, Mano H, Sugimoto K, Miyazono K. MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation. Mol Cell, 2011; 44(3): 424-436.
  10. Matsuyama H, Suzuki HI, Nishimori H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K, Miyazono K. miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma. Blood. 2011; 22; 118(26): 6881-92.
  11. Suzuki HI, Yamagata K, Sugimoto K, Iwamoto T, Kato S, Miyazono K. Modulation of microRNA processing by p53. Nature, 2009; 460(7254): 529-533.

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2020

  1. Ochi Y, Kon A, Sakata T, Nakagawa MM, Nakazawa N, Kakuta M, Kataoka K, Koseki H, Nakayama M, Morishita D, Tsuruyama T, Saiki R, Yoda A, Okuda R, Yoshizato T, Yoshida K, Shiozawa Y, Nannya Y, Kotani S, Kogure Y, Kakiuchi N, Nishimura T, Makishima H, Malcovati L, Yokoyama A, Takeuchi K, Sugihara E, Sato TA, Sanada M, Takaori-Kondo A, Cazzola M, Kengaku M, Miyano S, Shirahige K, Suzuki HI, Ogawa S. Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes. Cancer Discov. 2020 Jun;10(6):836-853.
  2. Tomofuji Y, Takaba H, Suzuki HI, Benlaribi R, Martinez CDP, Abe Y, Morishita Y, Okamura T, Taguchi A, Kodama T, Takayanagi H. Chd4 choreographs self-antigen expression for central immune tolerance. Nat Immunol. 2020 Jun 29. Online ahead of print.
  3. Ochi Y, Kon A, Sakata T, Nakagawa MM, Nakazawa N, Kakuta M, Kataoka K, Koseki H, Nakayama M, Morishita D, Tsuruyama T, Saiki R, Yoda A, Okuda R, Yoshizato T, Yoshida K, Shiozawa Y, Nannya Y, Kotani S, Kogure Y, Kakiuchi N, Nishimura T, Makishima H, Malcovati L, Yokoyama A, Takeuchi K, Sugihara E, Sato TA, Sanada M, Takaori-Kondo A, Cazzola M, Kengaku M, Miyano S, Shirahige K, Suzuki HI, Ogawa S. Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes. Cancer Discov, 2020; 10(6): 836-853.

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2019

  1. Matsuyama H, Suzuki HI. Systems and Synthetic microRNA Biology: From Biogenesis to Disease Pathogenesis. Int J Mol Sci, 2019; 21(1): 132.
  2. Tominaga K, Suzuki HI. TGF-β Signaling in Cellular Senescence and Aging-Related Pathology. Int J Mol Sci, 2019; 20(20): 5002.
  3. Kelly TJ, Suzuki HI, Zamudio JR, Suzuki M, Sharp PA. Sequestration of microRNA-mediated target repression by the Ago2-associated RNA-binding protein FAM120A. RNA, 2019; 25(10): 1291-1297.
  4. Akatsu Y, Takahashi N, Yoshimatsu Y, Kimuro S, Muramatsu T, Katsura A, Maishi N, Suzuki HI, Inazawa J, Hida K, Miyazono K, Watabe T. Fibroblast growth factor signals regulate transforming growth factor-β-induced endothelial-to-myofibroblast transition of tumor endothelial cells via Elk1. Mol Oncol, 2019; 13(8): 1706-1724.
  5. Grigelioniene G, Suzuki HI, Taylan F, Mirzamohammadi F, Borochowitz ZU, Ayturk UM, Tzur S, Horemuzova E, Lindstrand A, Weis MA, Grigelionis G, Hammarsjö A, Marsk E, Nordgren A, Nordenskjöld M, Eyre DR, Warman ML, Nishimura G, Sharp PA, Kobayashi T. Gain-of-function mutation of microRNA-140 in human skeletal dysplasia. Nat Med, 2019; 25(4): 583-590.
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2018

  1. Souma K, Shichino S, Hashimoto S, Ueha S, Tsukui T, Nakajima T, Suzuki HI, Shand FHW, Inagaki Y, Nagase T, Matsushima K. Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis. Sci Rep, 2018; 8(1): 16642.
  2. Gao A, Shrinivas K, Lepeudry P, Suzuki HI, Sharp PA, Chakraborty AK. Evolution of weak cooperative interactions for biological specificity. Proc Natl Acad Sci U S A, 2018; 115(47): E11053-E11060.
  3. Suzuki HI, Horie M, Mihira H, Saito A. Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling. J Vis Exp, 2018; (138): 57577.
  4. Miyashita N, Horie M, Suzuki HI, Yoshihara M, Djureinovic D, Persson J, Brunnström H, Lindskog C, Elfving H, Micke P, Saito A, Nagase T. An Integrative Analysis of Transcriptome and Epigenome Features of ASCL1-Positive Lung Adenocarcinomas. J Thorac Oncol, 2018; 13(11): 1676-1691.
  5. Suzuki HI. MicroRNA Control of TGF-β Signaling. Int J Mol Sci, 2019; 19(7): 1901.
  6. Suzuki HI, Spengler RM, Grigelioniene G, Kobayashi T, Sharp PA. Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics. Nat Genet, 2018; 50(5): 657-661.
  7. Chiu AC, Suzuki HI, Wu X, Mahat DB, Kriz AJ, Sharp PA. Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP. Mol Cell. 2018; 15; 69(4): 648-663.e7.
  8. Lai HH, Li JN, Wang MY, Huang HY, Croce CM, Sun HL, Lyu YJ, Kang JW, Chiu CF, Hung MC, Suzuki HI, Chen PS. HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis. J Clin Invest, 2018; 128(2): 625-643.
  9. Horie M, Miyashita N, Mikami Y, Noguchi S, Yamauchi Y, Suzukawa M, Fukami T, Ohta K, Asano Y, Sato S, Yamaguchi Y, Ohshima M, Suzuki HI, Saito A, Nagase T. TBX4 is involved in the super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts. Am J Physiol Lung Cell Mol Physiol, 2018; 314(1): L177-L191. J Clin Invest, 2018; 128(2): 625-643.
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2017

  1. Nissim L, Wu MR, Pery E, Binder-Nissim A, Suzuki HI, Stupp D, Wehrspaun C, Tabach Y, Sharp PA, Lu TK. Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy. Cell, 2017; 171(5): 1138-1150.
  2. Suzuki HI, Katsura A, Mihira H, Horie M, Saito A, Miyazono K. Regulation of TGF-β-mediated endothelial-mesenchymal transition by microRNA-27. J Biochem, 2017; 161(5): 417-420.
  3. Suzuki HI, Young RA, Sharp PA. Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis. Cell, 2017; 168(6): 1000-1014.

2016

  1. Horie M, Saito A, Ohshima M, Suzuki HI, Nagase T. YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer. Cancer Sci, 2016; 107(12): 1755-1766.
  2. Katsura A, Suzuki HI, Ueno T, Mihira H, Yamazaki T, Yasuda T, Watabe T, Mano H, Yamada Y, Miyazono K. MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β. Genes Cells, 2016; 21(1): 99-116.

2015

  1. Shichino S, Abe J, Ueha S, Otsuji M, Tsukui T, Kosugi-Kanaya M, Shand FH, Hashimoto S, Suzuki HI, Morikawa T, Inagaki Y, Matsushima K. Reduced supply of monocyte-derived macrophages leads to a transition from nodular to diffuse lesions and tissue cell activation in silica-induced pulmonary fibrosis in mice. Am J Pathol, 2015; 185(11): 2923-2938.
  2. Sugimoto K, Suzuki HI, Fujimura T, Ono A, Kaga N, Isobe Y, Sasaki M, Taka H, Miyazono K, Komatsu N. A clinically attainable dose of L-asparaginase targets glutamine addiction in lymphoid cell lines. Cancer Sci, 2015; 106(11): 1534-1543.
  3. Suzuki HI, Katsura A, Yasuda T, Ueno T, Mano H, Sugimoto K, Miyazono K. Small-RNA asymmetry is directly driven by mammalian Argonautes. Nat Struct Mol Biol, 2015; 22(7): 512-521.
  4. Suzuki HI, Katsura A, Miyazono K. A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B. Cancer Sci, 2015; 106(9): 1174-1181.
  5. Itami S, Eguchi Y, Mizutani T, Aoki E, Ohgi T, Kuroda M, Ochiya T, Kato N, Suzuki HI, Kawada N, Murakami Y. Control of HCV Replication With iMIRs, a Novel Anti-RNAi Agent. Mol Ther Nucleic Acids, 2015; 4(1): e219.
  6. Suzuki HI, Katsura A, Matsuyama H, Miyazono K. MicroRNA regulons in tumor microenvironment. Oncogene, 2015; 34(24): 3085-3094.

2014

  1. Horie M, Saito A, Noguchi S, Yamaguchi Y, Ohshima M, Morishita Y, Suzuki HI, Kohyama T, Nagase T. Differential knockdown of TGF-β ligands in a three-dimensional co-culture tumor- stromal interaction model of lung cancer. BMC Cancer, 2014; 14: 580.
  2. Noguchi S, Saito A, Horie M, Mikami Y, Suzuki HI, Morishita Y, Ohshima M, Abiko Y, Mattsson JS, König H, Lohr M, Edlund K, Botling J, Micke P, Nagase T. An integrative analysis of the tumorigenic role of TAZ in human non-small cell lung cancer. Clin Cancer Res, 2014; 20(17): 4660-4672.
  3. Tanaka M, Suzuki HI, Shibahara J, Kunita A, Isagawa T, Yoshimi A, Kurokawa M, Miyazono K, Aburatani H, Ishikawa S, Fukayama M. EVI1 oncogene promotes KRAS pathway through suppression of microRNA-96 in pancreatic carcinogenesis. Oncogene, 2014; 33(19): 2454-2463.

2013

  1. Yoshimatsu Y, Lee YG, Akatsu Y, Taguchi L, Suzuki HI, Cunha SI, Maruyama K, Suzuki Y, Yamazaki T, Katsura A, Oh SP, Zimmers TA, Lee SJ, Pietras K, Koh GY, Miyazono K, Watabe T. Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression. Proc Natl Acad Sci U S A, 2013; 110(47): 18940-18945.
  2. Suzuki HI, Matsuyama H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K, Miyazono K. Computational dissection of distinct microRNA activity signatures associated with peripheral T cell lymphoma subtypes. Leukemia, 2013; 27(10): 2107-2111.
  3. Saito A, Suzuki HI, Horie M, Ohshima M, Morishita Y, Abiko Y, Nagase T. An integrated expression profiling reveals target genes of TGF-β and TNF-α possibly mediated by microRNAs in lung cancer cells. PLoS One, 2013; 8(2): e56587.
  4. Suzuki HI, Mihira H, Watabe T, Sugimoto K, Miyazono K. Widespread inference of weighted microRNA-mediated gene regulation in cancer transcriptome analysis. Nucleic Acids Res, 2013; 41(5): e62.
  5. Suzuki HI, Miyazono K. p53 actions on microRNA expression and maturation pathway. Methods Mol Biol, 2013; 962: 165-181.
  6. Liang C, Xiong K, Szulwach KE, Zhang Y, Wang Z, Peng J, Fu M, Jin P, Suzuki HI, Liu Q.. Sjogren syndrome antigen B (SSB)/La promotes global microRNA expression by binding microRNA precursors through stem-loop recognition. J Biol Chem, 2013; 288(1): 723-736.

Join us!

We are recruiting staff and graduate students from all over the world. Please send your curriculum vitae, bibliography, and a letter describing your research or clinical experience by e-mail to us.

Contact

Lab address: Nagoya University Medical Science Research Building 3, 505-1 65 Tsurumai-cho, Showa-ku Nagoya city Japan Postal code: 466-8550

Tel: +81-52-744-2460

Email: hisuzuki@med.nagoya-u.ac.jp